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Protease inhibitors in new drug therapy: an overview.
Protease inhibitors (PIs) have a demonstrated potential for the treatment of HIV disease and increasingly for the treatment of other viral infections of immune competent individuals. This potential is due to a number of factors including the availability of potent and effective inhibitors of the protease enzyme from the HIV-1 virus, the rapidity with which viruses can be generated to overcome these inhibitors, the essential nature of the pr